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Hull have won only won one of their last seven matches against Sheffield Wednesday in all competitions (D4 L2), a 1-0 win in the 2015-16 Championship play-off final.
Sheffield Wednesday are unbeaten in three away Championship visits to Hull (W2 D1) since losing three in a row between 2005 and 2007.
Hull are looking to win six straight league games in the second tier or above for the first time since April 1910 under manager Ambrose Langley.
Sheffield Wednesday have not lost an away Yorkshire derby in the league since February 2017 (0-1 v Leeds United), winning three and drawing four of their last seven such trips.
Fraizer Campbell has scored two goals in three games against Sheffield Wednesday for Hull City, including netting the opener in the reverse fixture earlier this season.
Sheffield Wednesday will have a new manager at the helm for the fifth straight visit to the KCOM Stadium, after Brian Laws, Dave Jones, Carlos Carvalhal, Jos Luhukay and now Steve Agnew/Stephen Clemence.